:root{color-scheme:light;--bg:#f3f2e9;--surface:#fffef8;--subtle:#eaeedd;--ink:#243c30;--muted:#586759;--border:#c7cdbb;--accent:#326348;--virus:#b84a37;--signal:#337c81;--cells:#4e762a;--adaptive:#755596;--symptoms:#a36c12;--track:#dae0cf}*{box-sizing:border-box}body{margin:0;background:var(--bg);color:var(--ink);font:14px/1.5 system-ui,sans-serif}main{max-width:1180px;margin:auto;padding:24px 28px}h1{font-size:19px;margin:0;font-weight:750;letter-spacing:-.5px}h1 span{font-weight:400;color:var(--muted)}h2{margin:0;font-size:30px;letter-spacing:-1px}h3{font-size:14px;margin:0;font-weight:750}p{margin:8px 0 16px}.top,.context,.time-head,.plot-head{display:flex;align-items:center;justify-content:space-between;gap:12px}.context{justify-content:flex-start;margin:16px 0;color:var(--muted);font-size:12px}.tag{border:1px solid var(--border);border-radius:20px;padding:3px 9px;color:var(--ink);background:var(--subtle)}button{font:inherit;font-size:12px;border:1px solid var(--border);background:var(--surface);color:var(--ink);padding:6px 10px;border-radius:8px;cursor:pointer}button:hover,button[aria-pressed=true]{background:var(--subtle);border-color:var(--accent)}button:focus-visible,a:focus-visible,input:focus-visible,summary:focus-visible{outline:3px solid var(--signal);outline-offset:3px}.workspace{display:grid;grid-template-columns:minmax(0,1.7fr) minmax(290px,1fr);border:1px solid var(--border);background:var(--surface);border-radius:15px;overflow:hidden}.primary{padding:24px}aside{padding:24px;border-left:1px solid var(--border)}.time-head span{color:var(--muted)}input[type=range]{display:block;accent-color:var(--accent);width:100%;margin:15px 0 5px;cursor:pointer;min-height:24px}.ticks{display:flex;justify-content:space-between;color:var(--muted);font-size:11px}.stages{display:flex;gap:6px;margin:18px 0 24px;flex-wrap:wrap}.plot-head{align-items:baseline}.plot-head span{font-size:11px;color:var(--muted)}.chart{display:block;width:100%;height:205px;margin-top:12px;cursor:crosshair}.plot-ticks{padding-left:27px}.series-button{padding:3px 5px;border-color:transparent;background:transparent;font-size:12px;text-align:left}.dot{width:9px;height:9px;display:inline-block;flex-shrink:0;border-radius:50%;margin-right:7px}.detail{margin-top:18px;border-left:3px solid var(--accent);padding-left:12px;font-size:12px;min-height:64px}.detail p{margin:4px 0 0;color:var(--muted)}.muted{color:var(--muted);font-size:12px}.airway{height:174px;border:1px solid var(--border);border-radius:10px;overflow:hidden;background:var(--subtle)}.lumen,.tissue{height:75px;position:relative}.region-label{position:absolute;top:5px;left:8px;font-size:10px;color:var(--muted);z-index:1}.virion,.immune{position:absolute;color:var(--virus);opacity:0;font-size:19px}.immune{color:var(--cells);font-size:22px}.visible{opacity:1}.epithelium{display:flex;height:24px;gap:3px;padding:0 4px}.epithelial{background:var(--accent);opacity:.65;border:1px solid var(--ink);flex:1;border-radius:7px 7px 3px 3px}.epithelial.infected{background:var(--virus);opacity:1}.legend{font-size:10px;color:var(--muted);display:flex;gap:12px;flex-wrap:wrap;margin:10px 0}.legend span{display:flex;align-items:center}.stage-copy{font-size:13px;min-height:80px}.assumptions{border-top:1px solid var(--border);padding-top:16px}.assumptions label{display:flex;justify-content:space-between;gap:10px;font-size:12px;margin-top:14px}.assumptions output{color:var(--accent);font-weight:700}.assumptions input{margin-top:3px}.assumptions button{margin-top:15px}.assumptions p:last-child{margin-bottom:0}details{border:1px solid var(--border);border-radius:10px;background:var(--surface);margin-top:12px}summary{padding:13px 16px;cursor:pointer;font-weight:600;font-size:13px}.notes{max-width:850px;padding:0 20px 6px;font-size:13px}a{color:var(--accent);text-underline-offset:3px}footer{font-size:11px;color:var(--muted);margin-top:16px}.sr{position:absolute;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip:rect(0,0,0,0);white-space:nowrap;border:0}[v-cloak]{display:none}#startup{padding:25px}@media(max-width:760px){main{padding:16px 12px}h1{font-size:16px}h1 span{display:block;font-size:12px}.context{flex-wrap:wrap;gap:7px}.workspace{grid-template-columns:1fr}.primary,aside{padding:18px}aside{border-left:0;border-top:1px solid var(--border)}.plot-head{display:block}.plot-head span{display:block;margin-top:4px}.stage-copy{min-height:0}.time-head span{font-size:12px}.series-button{font-size:11px}.chart{height:190px}}@media(prefers-reduced-motion:no-preference){button{transition:background .12s}}

.signalling{margin-top:20px;padding:22px;border:1px solid var(--border);border-radius:15px;background:var(--surface);scroll-margin-top:16px}.signalling h2{font-size:21px;letter-spacing:-.4px}.signalling>p{max-width:780px}.signalling figure{margin:16px 0}.signalling img{display:block;width:100%;height:auto;border:1px solid var(--border);border-radius:10px;background:#fffef8;color:#243c30}.signalling figcaption{font-size:12px;color:var(--muted);margin-top:8px}.signal-explanation{margin:18px 0 0}.signal-explanation>div{display:grid;grid-template-columns:150px 1fr;gap:16px;padding:12px 0;border-top:1px solid var(--border)}.signal-explanation dt{font-weight:700}.signal-explanation dd{margin:0;max-width:780px}@media(max-width:760px){.signalling{padding:16px}.signal-explanation>div{grid-template-columns:1fr;gap:4px}}

.chart-mode{display:flex;align-items:center;justify-content:space-between;gap:8px;min-height:36px;color:var(--muted);font-size:11px}.chart-mode button{padding:4px 8px}

.series-button:hover,.series-button.is-active{background:transparent;border-color:transparent}.series-button.is-active{text-decoration:underline;text-decoration-thickness:2px;text-underline-offset:4px}

.curve-legend{display:flex;flex-wrap:wrap;align-items:center;gap:5px 14px;margin-top:16px}.curve-legend .series-button{display:inline-flex;align-items:center;white-space:nowrap}

:root{--text:var(--ink);--active:var(--subtle)}